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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
31/03/2022 |
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Data da última atualização: |
31/03/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GOLDONI, I.; IBELLI, A. M. G.; FERNANDES, L. T.; PEIXOTO, J. de O.; HUL, L. M.; CANTAO, M. E.; GOUVEIA, J. J. de S.; LEDUR, M. C. |
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Afiliação: |
IARA GOLDONI, Unicentro/Guarapuava; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; LANA LANA TEIXEIRA FERNANDES; JANE DE OLIVEIRA PEIXOTO, CNPSA; LLUDMILA MUDRI HUL, Unicentro/Guarapuava; MAURICIO EGIDIO CANTAO, CNPSA; JOÃO JOSÉ DE SIMONI GOUVEIA, UNIVASF; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Comprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Animals, v. 12, n. 788, 2022. |
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DOI: |
https://doi.org/10.1016/j.indcrop.2022.114800 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS/FHN in chickens and humans. |
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Palavras-Chave: |
Análise integrada; Expressão genetica; Inflammatory response; Integrated analysis; Necrose da cabeça femoral; Polimorfismos de nucleotídeo único; Resposta inflamatória; SNPs. |
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Thesaurus Nal: |
Gene expression; Single nucleotide polymorphism. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02411naa a2200337 a 4500
001 2141675
005 2022-03-31
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.indcrop.2022.114800$2DOI
100 1 $aGOLDONI, I.
245 $aComprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation.$h[electronic resource]
260 $c2022
520 $aAbstract: Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS/FHN in chickens and humans.
650 $aGene expression
650 $aSingle nucleotide polymorphism
653 $aAnálise integrada
653 $aExpressão genetica
653 $aInflammatory response
653 $aIntegrated analysis
653 $aNecrose da cabeça femoral
653 $aPolimorfismos de nucleotídeo único
653 $aResposta inflamatória
653 $aSNPs
700 1 $aIBELLI, A. M. G.
700 1 $aFERNANDES, L. T.
700 1 $aPEIXOTO, J. de O.
700 1 $aHUL, L. M.
700 1 $aCANTAO, M. E.
700 1 $aGOUVEIA, J. J. de S.
700 1 $aLEDUR, M. C.
773 $tAnimals$gv. 12, n. 788, 2022.
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| 1. |  | SANTOS, A. F. dos; AUER, C. G. Manejo fitossanitário. In: GOMES, L. J.; SILVA-MANN, R.; MATTOS, P. P. de; RABBANI, A. R. C. Pensando a biodiversidade: aroeira (Schinus terebinthifolius RADDI.). São Cristóvão: Ed. UFS, 2013. p. 221-226. e-book.| Tipo: Capítulo em Livro Técnico-Científico |
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